Natural killer cells are a source of interferon gamma that drives differentiation of CD4+ T cell subsets and induces early resistance to Leishmania major in mice.
Scharton et al, J. Exp. Med. August 1993.
The adjuvant effect of interleukin-12 in a vaccine against Leishmania major.
Afonso et al, Science, January 1994.
IL-12 is required for natural killer cell activation and subsequent T helper 1 cell development in experimental leishmaniasis.
Scharton et al, J Immunol, May 1995
In the absence of endogenous IFN-gamma, mice develop unimpaired IL-12 responses to Toxoplasma gondii while failing to control acute infection.
Scharton et al, J Immunol, November 1996
Leishmania major-infected C3H mice treated with anti-IL-12 mAb develop but do not maintain a Th2 response
Hondowicz et al, J Immunol, November 1997